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A 33-year-old woman presented with a 3-year history of progressive numbness in the hand,cerebellar ataxia,limb weakness,nystagmus,and dysarthria.T2-weighted MRI revealed abnormal foci of increased signal intensity mimicking demyelinating plaques in the periventricular white matter,and brain FDG-PET scan showed increased uptake in the pons.Biopsy from a tibial lesion showed aggregates of foamy histiocytes in the intertrabecular spaces replacing the bone marrow,characteristic of Erdheim-Chester disease.The patient was treated with craniospinal radiation.After 6 months,the clinical picture was stable and the MRI was unchanged. |
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arthralgia
ataxia
ataxia,cerebellar
bone marrow biopsy
CAT scan,emission,abnormal
CAT scan,false negative
diabetes insipidus
dysarthria
Erdheim-Chester disease
gait disorder
histiocytosis
long bone lesion
misdiagnosis
MRI
MRI,abnormal
multiple sclerosis,differential diagnosis of
multiple sclerosis,misdiagnosis
nystagmus
osteoblastic lesions,causes of
treatment of neurologic disorder
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